Thomas E Smithgall Selected Research

src-Family Kinases

1/2020	In Vitro Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance.
7/2010	Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.
11/2007	Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.
10/2006	Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
9/2006	HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.
9/2004	SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.
8/2003	Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.
11/2002	Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
11/2002	The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.

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Thomas E Smithgall Research Topics

Disease

19	Neoplasms (Cancer) 07/2021 - 04/2002
14	Acquired Immunodeficiency Syndrome (AIDS) 10/2020 - 11/2004
6	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 03/2013 - 11/2002
5	Infections 09/2015 - 12/2004
5	Carcinogenesis 01/2012 - 11/2002
5	Squamous Cell Carcinoma of Head and Neck 05/2006 - 04/2002
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 01/2017
3	Inflammation (Inflammations) 01/2022 - 03/2010
3	Colorectal Neoplasms (Colorectal Cancer) 03/2010 - 03/2006
2	Hematologic Neoplasms (Hematological Malignancy) 10/2018 - 01/2018
2	Leukemia 01/2016 - 02/2009
2	Virus Diseases (Viral Diseases) 01/2015 - 10/2011
2	Head and Neck Neoplasms (Head and Neck Cancer) 09/2004 - 04/2002
2	Myeloid Leukemia (Leukemia, Myelocytic) 11/2002 - 11/2002
1	Communicable Diseases (Infectious Diseases) 07/2021
1	Chronic Disease (Chronic Diseases) 10/2020
1	Neoplasm Metastasis (Metastasis) 08/2015
1	Chickenpox 01/2015
1	Herpes Zoster 01/2015
1	Rubella (German Measles) 01/2015
1	Cognitive Dysfunction 12/2013
1	Colonic Neoplasms (Colon Cancer) 03/2010
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2009
1	Leukopenia 04/2004
1	Anemia 04/2004

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 11/2019 - 08/2003
13	Phosphotransferases (Kinase)IBA 01/2020 - 11/2002
10	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 11/2002
9	src-Family KinasesIBA 01/2020 - 11/2002
7	Pharmaceutical PreparationsIBA 07/2021 - 11/2009
3	ErbB Receptors (EGF Receptor)IBA 05/2006 - 04/2002
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2021 - 01/2017
2	Tyrosine (L-Tyrosine)FDA Link 10/2018 - 03/2006
2	bcr-abl Fusion ProteinsIBA 03/2013 - 11/2002
2	Imatinib Mesylate (Gleevec)FDA Link 02/2013 - 07/2010
2	Gastrin-Releasing PeptideIBA 05/2006 - 09/2004
2	nef Gene Products (nef Gene Product)IBA 12/2004 - 11/2004
2	Protein Isoforms (Isoforms)IBA 10/2003 - 04/2002
1	Codon (Codons)IBA 01/2020
1	Choline KinaseIBA 11/2019
1	Interleukin-17 (Interleukin 17)IBA 09/2015
1	EndoribonucleasesIBA 09/2015
1	Focal Adhesion Protein-Tyrosine KinasesIBA 08/2015
1	LuciferasesIBA 01/2015
1	Conditioned Culture MediaIBA 01/2015
1	MicroRNAs (MicroRNA)IBA 01/2015
1	Biological ProductsIBA 01/2014
1	Myristic Acid (Tetradecanoic Acid)IBA 03/2013
1	MethyltransferasesIBA 03/2010
1	DNA (Deoxyribonucleic Acid)IBA 03/2010
1	Transcription Factors (Transcription Factor)IBA 03/2010
1	Decitabine FDA Link 03/2010
1	NF-kappa B (NF-kB)IBA 03/2010
1	Oncogene Proteins (Oncogene Protein)IBA 06/2009
1	Small Interfering RNA (siRNA)IBA 01/2009
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2007
1	Protein Kinases (Protein Kinase)IBA 11/2006
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 05/2006
1	Anti-HIV Agents (AIDS Drugs)IBA 11/2004
1	AmphiregulinIBA 09/2004
1	Transforming Growth Factor alpha (TGF-alpha)IBA 09/2004
1	LigandsIBA 09/2004
1	Epidermal Growth Factor (EGF)IBA 09/2004
1	Matrix Metalloproteinase InhibitorsIBA 09/2004
1	marimastatIBA 09/2004
1	Bombesin Receptors (Bombesin Receptor)IBA 09/2004
1	ArsenicIBA 04/2004
1	Antisense OligonucleotidesIBA 10/2003
1	CytokinesIBA 11/2002
1	pyrimidineIBA 11/2002
1	STAT5 Transcription FactorIBA 11/2002

Therapy/Procedure

6	Therapeutics 10/2020 - 07/2007
1	Transcutaneous Electric Nerve Stimulation (TENS) 01/2022